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| Award | Year (↑) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Golden Gasm Award | 2005 | Best Television Series, Scripted | Nominee | |
| Future Classic Award | 2005 | Winner | ||
| Emmy Award | 2005 | Outstanding Writing for a Comedy Series | Nominee | Marc Cherry |
| TV Times Readers' Choice | 2005 | TV Show You Try Not to Miss (#4) | Voted | |
| Cadet Award | 2005 | Outstanding Writing in a Comedy Series | Winner | Marc Cherry |
| E!'s 101 Lists | 2005 | 101 Even Bigger Celebrity Oops! (#61) | Winner | Heather Locklear, Calista Flockhart, Mary Louise Parker turn down roles |
| PRISM Award | 2005 | Outstanding Television Comedy Series Episode | Nominee | |
| Online Television Academy Award | 2005 | Best Costume Design in a Television Series | Nominee | |
| Directors Guild Award | 2005 | Outstanding Directorial Achievement in Television Comedy Series | Nominee | Charles McDougall |
| Directors Guild Award | 2005 | Outstanding Directorial Achievement in Television Comedy Series | Nominee | Arlene Sanford |
| Amy Award | 2005 | I Don't Love to Hate You, I Just Hate You (a.k.a. Worst Character) | Nominee | Zach |
| Internet TV Award | 2005 | Favorite Actress in a Primetime Comedy Series | Nominee | Teri Hatcher |
| Golden Globe Award | 2005 | Outstanding Supporting Actress in a Television Series, Miniseries or Made-for-TV Movie | Nominee | Nicollette Sheridan |
| Internet TV Award | 2005 | Favorite Actress in a Primetime Comedy Series | Nominee | Felicity Huffman |
| Internet TV Award | 2005 | Favorite Actress in a Primetime Comedy Series | Nominee | Eva Longoria |
| Tubey Award | 2005 | The ''Great, Now Every Burrito I See Reminds Me of Lacy Red Panties (and Vice Versa)'' Award | Winner | Bree Van de Kamp |
| Amy Award | 2005 | The Shame Award (a.k.a. Most Unrealistic or Insensitive Portrayal of a Segment of the Population) | Nominee | Andrew is gay and evil |
| Golden Globe Award | 2005 | Outstanding Television Comedy or Musical Series | Winner | |
| Online Television Academy Award | 2005 | Best Direction in a Comedy Series | Nominee | |
| RATTY Award | 2005 | Best Lead Actress in a Comedy Series | Nominee | Marcia Cross |
| PRISM Award | 2005 | Outstanding Television Comedy Series Multi-Episode Storyline | Winner | |
| Emmy Award | 2005 | Outstanding Lead Actress in a Comedy Series | Nominee | Marcia Cross |
| RATTY Award | 2005 | Best Lead Actress in a Comedy Series | Nominee | Teri Hatcher |
| Amy Award | 2005 | It's Getting Hot in Here (a.k.a. Female Character We Would Most Like to See Naked) | Winner | Gabrielle |
| Emmy Award | 2005 | Outstanding Lead Actress in a Comedy Series | Nominee | Teri Hatcher |
| PRISM Award | 2005 | Outstanding Performance in a Television Comedy Series | Nominee | Marcia Cross |
| RATTY Award | 2005 | Best Lead Actress in a Comedy Series | Nominee | Felicity Huffman |
| Emmy Award | 2005 | Outstanding Lead Actress in a Comedy Series | Winner | Felicity Huffman |
| PRISM Award | 2005 | Outstanding Performance in a Television Comedy Series | Nominee | Felicity Huffman |
| People Magazine's Best/Worst List | 2005 | 10 Sizzling Shows | Winner | |
| Artios Award | 2005 | Best Casting for a Comedy Pilot | Winner | Junie Lowry Johnson; Scott Genkinger |
| TV Times Readers' Choice | 2005 | Best Comedy Series (#1) | Voted | |
| Online Television Academy Award | 2005 | Best Writing in a Comedy Series | Nominee | |
| RATTY Award | 2005 | Best New Series | Nominee | |
| TV Times Readers' Choice | 2005 | Best Actress in a Comedy (#1) | Voted | Teri Hatcher |
| Cadet Award | 2005 | Top 12 Scenes or Lines | Winner | |
| TV Times Readers' Choice | 2005 | Best Actress in a Comedy (#4) | Voted | Marcia Cross |
| USA Today's Best & Worst of TV | 2005 | Best of TV (#10) | Winner | |
| Online Television Academy Award | 2005 | Best Ensemble Cast in a Comedy Series | Nominee | |
| Amy Award | 2005 | The Verklempt Award (a.k.a. Most Touching Scene) | Nominee | Bree breaking down after Rex dies |
| Emmy Award | 2005 | Outstanding Main Title Design | Nominee | Garson Yu; Yolanda Santosa |
| Teen Choice Award | 2005 | Choice TV Breakout Performance, Female | Winner | Eva Longoria |
| Teen Choice Award | 2005 | Choice TV Breakout Performance, Male | Winner | Jesse Metcalfe |
| Banff Rockie Award | 2005 | Best Continuing Series | Winner | |
| Teen Choice Award | 2005 | Choice TV Breakout Show | Winner | |
| Emmy Award | 2005 | Outstanding Main Title Theme Music | Winner | Danny Elfman |
| Artios Award | 2005 | Best Casting for an Episodic Comedy Series | Nominee | Junie Lowry Johnson; Scott Genkinger |
| Teen Choice Award | 2005 | Choice V-Cast | Winner | |
| Online Television Academy Award | 2005 | Best Music in a Television Series | Nominee | |
| BMI TV Music Award | 2005 | Winner | Danny Elfman; Steve Bartek; Stewart Copeland; Steve Jablonsky |
