Once and Again
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| Award | Year (↑) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Electronic Media's Critics Poll | 2000.07 | Best Television Series (#7) | Winner | |
| Online Television Academy Award | 2001 | Best Lead Actor in a Drama Series | Nominee | Billy Campbell |
| Emmy Award | 2001 | Outstanding Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Golden Globe Award | 2001 | Outstanding Actress in a Television Drama Series | Winner | Sela Ward |
| Online Television Academy Award | 2001 | Best Lead Actress in a Drama Series | Winner | Sela Ward |
| Petcabus Award | 2001 | Best Ensemble Cast in a Drama Series | Nominee | |
| Cadet Award | 2001 | Outstanding Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| Online Television Academy Award | 2001 | Best Ensemble Cast in a Drama Series | Nominee | |
| Writers Guild Award | 2001 | Best Writing in an Episodic Drama Series for Television | Nominee | Richard Kramer |
| Petcabus Award | 2001 | Best Recurring or Guest Actor or Actress in a Comedy or Drama Series | Nominee | Patrick Dempsey |
| RATTY Award | 2001 | Best Drama Series | Nominee | |
| Cadet Award | 2001 | Outstanding Lead Actor in a Drama Series | Winner | Billy Campbell |
| TV Guide Award (televised) | 2001 | Favorite Actress in a Drama Series | Nominee | Sela Ward |
| Cadet Award | 2001 | Outstanding Lead Actress in a Drama Series | Nominee | Sela Ward |
| RATTY Award | 2001 | Best Lead Actress in a Drama Series | Nominee | Sela Ward |
| Entertainment Weekly's Best/Worst List | 2001 | The Ten Best (#8) | Winner | |
| Cadet Award | 2001 | Outstanding Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| Cadet Award | 2001 | Outstanding Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| RATTY Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Susanna Thompson |
| RATTY Award | 2001 | Best Supporting Actress in a Drama Series | Nominee | Evan Rachel Wood |
| RATTY Award | 2001 | Best Writing in a Drama Series | Winner | Marshall Herskovitz, Ed Swick |
| RATTY Award | 2001 | Best Directing in a Drama Series | Nominee | Dan Lerner |
| Online Television Academy Award | 2001 | Best Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| RATTY Award | 2001 | Best Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Online Television Academy Award | 2001 | Best Guest Actress in a Drama Series | Nominee | Barbara Barrie |
| Online Television Academy Award | 2001 | Best Direction in a Drama Series | Nominee | |
| Cadet Award | 2001 | Outstanding Guest Actor in a Drama Series | Nominee | Patrick Dempsey |
| Cadet Award | 2001 | Outstanding Guest Actress in a Drama Series | Nominee | Barbara Barrie |
| Online Television Academy Award | 2001 | Best Writing in a Drama Series | Nominee | |
| Young Artist Award | 2001 | Best Performance by a Young Ensemble in a Television Comedy or Drama Series | Winner | |
| Cadet Award | 2001 | Outstanding Writing in a Drama Series | Nominee | Winnie Holzman |
| Cadet Award | 2001 | Outstanding Directing in a Drama Series | Nominee | Dan Lerner |
| Emmy Award | 2001 | Outstanding Casting for a Drama Series | Nominee | Amy Lippens, Lizzie Scheck |
| Cadet Award | 2001 | Outstanding Music Composition (Dramatic Underscore) | Nominee | |
| futoncritic's Best Eps | 2001 | 20 Best Eps of 2000 (#16) | Winner | |
| Wand Award | 2001 | Best Chemistry | Nominee | Lily and Rick |
| futoncritic's Best Eps | 2001 | 20 Best Eps of 2000 (#7) | Winner | |
| USA Today's Best & Worst of TV | 2001 | Best of TV (#6) | Winner | |
| Humanitas Prize | 2001 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Winner | Marshall Herksovitz, Edward Zwick |
| Wand Award | 2001 | Best Show | Nominee | |
| Petcabus Award | 2001 | Best Drama Series | Nominee | |
| Golden Satellite Award | 2001 | Best Television Drama Series | Nominee | |
| Online Television Academy Award | 2001 | Best Episode in a Drama Series | Nominee | |
| Golden Satellite Award | 2001 | Best Actress in a Television Drama Series | Nominee | Sela Ward |
| Petcabus Award | 2001 | Best Actress in a Drama Series | Nominee | Sela Ward |
| Screen Actors Guild Award | 2001 | Outstanding Performance by an Actress in a Television Drama Series | Nominee | Sela Ward |
| Emmy Award | 2001 | Outstanding Lead Actress in a Drama Series | Nominee | Sela Ward |
| Viewers Voice Award | 2001 | Favorite Actor in a Drama Series | Nominee | Billy Campbell |
| Online Television Academy Award | 2001 | Best Drama Series | Nominee |
