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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Zap2it Best/Worst | 2007 | TV Gal's Best in Show (#10) | Winner | |
| Young Artist Award | 2008 | Best Performance by a Young Actress Guest-Starring in a Television Comedy or Drama Series | Nominee | Bailee Madison |
| Young Artist Award | 2007 | Best Performance by a Young Actor Guest-Starring in a Television Comedy or Drama Series | Nominee | Skyler Gisondo |
| Young Artist Award | 2006 | Best Performance by a Young Actress Guest-Starring in a Television Comedy or Drama Series | Nominee | Jennifer Stone |
| Writers Guild Award | 2006 | Best Writing in an Episodic Drama Series for Television | Winner | Lawrence Kaplow |
| Wave Awards | 2008 | Favorite Clipped Dramatic Series | Nominee | |
| Wave Awards | 2008 | Favorite Clipped Dramatic Artist | Nominee | Hugh Laurie |
| Voice Award | 2008 | Television | Winner | |
| USA Today's Best & Worst of TV | 2006 | Five Fabulous Performances, Female | Winner | Lisa Edelstein |
| USA Today's Best & Worst of TV | 2006 | Five Fabulous Performances, Male | Winner | Hugh Laurie |
| USA Today's Best & Worst of TV | 2005 | Best of TV (#3) | Winner | |
| TV Times Readers' Choice | 2005 | Best Drama Series (#3) | Voted | |
| TV Squad Award | 2008 | The Excellence in Outsourcing Award | Winner | Hugh Laurie |
| Tubey Award | 2007 | Worst Chemistry (#2) | Voted | Gregory House & Allison Cameron |
| Tubey Award | 2007 | Best Bad-Ass (#3) | Voted | Gregory House |
| Tubey Award | 2007 | Most Unwelcome New Character (#1) | Voted | Michael Tritter |
| Tubey Award | 2007 | Best HoYay! Moment (#3) | Voted | Although a big, romantic weekend in the Poconos could change everything |
| Tubey Award | 2007 | Best Returning Show (#3 - tie) | Voted | |
| Tubey Award | 2007 | Best Drama (#3) | Voted | |
| Tubey Award | 2007 | Worst Use of David Morse in a Television Show or Motion Picture | Winner | |
| Tubey Award | 2007 | Favourite Character (#1) | Voted | Gregory House |
| Tubey Award | 2007 | Favourite Actor (#1) | Voted | Hugh Laurie |
| Tubey Award | 2006 | Favourite Character (#1) | Voted | Gregory House |
| Tubey Award | 2006 | Favourite Actor (#1) | Voted | Hugh Laurie |
| Tubey Award | 2006 | Best Drama (#3) | Voted | |
| Tubey Award | 2006 | Best Sidekick (#1) | Voted | Wilson |
| Tubey Award | 2006 | Best Performance by an Inanimate Object (#2) | Voted | cane |
| Tubey Award | 2006 | Best Returning Show (#3) | Voted | |
| Tubey Award | 2006 | TWoP Show with Highest Actual Quality (#3) | Voted | |
| Tubey Award | 2006 | Show with the Most HoYay (#2) | Voted | |
| Tubey Award | 2005 | Best New Show (#3) | Voted | |
| Tubey Award | 2005 | Favourite Character (#2) | Voted | Gregory House |
| Tubey Award | 2005 | Favourite Actor (#1) | Voted | Hugh Laurie |
| Tubey Award | 2005 | Best Drama (#3) | Voted | |
| Tubey Award | 2005 | Most Questionable Advancement of Disabled Persons | Winner | |
| Tubey Award | 2005 | The ''No Wonder There's No Cure For Cancer'' Award | Winner | Dr. James Wilson |
| TelevisionWeek's Critics Poll | 2008.02 | Best Television (#6) | Winner | |
| TelevisionWeek's Critics Poll | 2008.01 | Best Television (#7) | Winner | |
| TelevisionWeek's Critics Poll | 2007.02 | Best Television (#15) | Winner | |
| TelevisionWeek's Critics Poll | 2007.01 | Best Television (#11) | Winner | |
| TelevisionWeek's Critics Poll | 2006.02 | Best Television (#5) | Winner | |
| TelevisionWeek's Critics Poll | 2006.01 | Best Television (#3) | Winner | |
| TelevisionWeek's Critics Poll | 2005.02 | Best Television (#6) | Winner | |
| TelevisionWeek's Critics Poll | 2005.01 | Best Television (#10) | Winner | |
| Television Critics Association Award | 2007 | Outstanding Individual Achievement in a Drama Series | Nominee | Hugh Laurie |
| Television Critics Association Award | 2006 | Outstanding Achievement in a Drama Series | Nominee | |
| Television Critics Association Award | 2006 | Outstanding Individual Achievement in a Drama Series | Winner | Hugh Laurie |
| Television Critics Association Award | 2005 | Outstanding Achievement in a Drama Series | Nominee | |
| Television Critics Association Award | 2005 | Outstanding Individual Achievement in a Drama Series | Winner | Hugh Laurie |
| Television Critics Association Award | 2005 | Outstanding New Program of the Year | Nominee |
