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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Writers Guild Award | 1989 | Best Writing in an Episodic Drama Series for Television | Nominee | Tom Fontana, John Tinker, Channing Gibson |
| Writers Guild Award | 1988 | Best Writing in an Episodic Drama Series for Television | Nominee | John Masius; Tom Fontana; Channing Gibson |
| Writers Guild Award | 1987 | Best Writing in an Episodic Drama Series for Television | Winner | John Massius; Bruce Paltrow; Tom Fontana |
| Writers Guild Award | 1985 | Best Writing in an Episodic Drama Series for Television | Nominee | John Masius; Tom Fontana |
| Writers Guild Award | 1985 | Best Writing in an Episodic Drama Series for Television | Nominee | John Ford Noonan |
| Viewers for Quality Television Award | 1987 | Best Actor in a Quality Drama Series | Winner | William Daniels |
| Viewers for Quality Television Award | 1987 | Best Supporting Actress in a Quality Drama Series | Winner | Bonnie Bartlett |
| Viewers for Quality Television Award | 1986 | Best Actor in a Quality Drama Series | Winner | William Daniels |
| Viewers for Quality Television Award | 1985 | Best Actor in a Quality Drama Series | Nominee | William Daniels |
| Viewers for Quality Television Award | 1985 | Best Supporting Actor in a Quality Drama Series | Nominee | Norman Lloyd |
| Viewers for Quality Television Award | 1985 | Best Actor in a Quality Drama Series | Nominee | Ed Flanders |
| Viewers for Quality Television Award | 1985 | Best Supporting Actor in a Quality Drama Series | Nominee | Ed Begley Jr. |
| Viewers for Quality Television Award | 1985 | Best Supporting Actress in a Quality Drama Series | Nominee | Karen Austin |
| Viewers for Quality Television Award | 1985 | Best Supporting Actress in a Quality Drama Series | Nominee | Christina Pickles |
| Viewers for Quality Television Award | 1985 | Best Supporting Actress in a Quality Drama Series | Nominee | Florence Halop |
| Viewers for Quality Television Award | 1985 | Best Supporting Actor in a Quality Drama Series | Nominee | David Morse |
| TV Guide's All Time Greatest/Worst Lists | 2005 | 100 Most Unexpected TV Moments (#10) | Winner | The series existed only in the imagination of an autistic child. |
| TV Guide's All Time Greatest/Worst Lists | 2004 | 100 Most Memorable TV Moments (#88) | Winner | The Saving Heart |
| TV Guide's All Time Greatest/Worst Lists | 2002 | 50 Greatest TV Shows (#20) | Winner | |
| TV Guide's All Time Greatest/Worst Lists | 1999 | 50 Greatest TV Characters (#41) | Winner | William Daniels Dr. Mark Craig |
| TV Guide's All Time Greatest/Worst Lists | 1997 | 100 Greatest TV Episodes (#44) | Winner | |
| TV DVD Awards | 2007 | Best 1980s Series | Nominee | |
| Time Magazine's 100 Best TV Shows | 2007 | One of the 100 Best TV Shows of All-Time | Winner | |
| TelevisionWeek's Best of 25 Years | 2007 | Broadcast's Best of Past 25 Years | Winner | |
| Television Critics Association Award | 1988 | Outstanding Drama Series | Winner | |
| People's Choice Award | 1983 | Favorite New Television Drama Series | Winner | |
| Peabody Award | 1985 | Winner | ||
| Maggie Award | 1986 | TV Series | Winner | |
| Humanitas Prize | 1985 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Winner | John Masius, Tom Fontana |
| Golden Globe Award | 1988 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 1987 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 1986 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 1986 | Outstanding Supporting Actor in a Television Series, Miniseries or Made-for-TV Movie | Nominee | Ed Begley Jr. |
| Golden Globe Award | 1985 | Outstanding Television Drama Series | Nominee | |
| Golden Eddie Award | 1988 | Best Edited Episode from a Television Series | Winner | Robert Seppey |
| Golden Eddie Award | 1987 | Best Edited Episode from a Television Series | Nominee | John Heath |
| Golden Eddie Award | 1986 | Best Edited Episode from a Television Series | Winner | Robert Seppey |
| EW's All Time Greatest/Worst Lists | 1999 | 100 Greatest TV Moments (#72) | Winner | |
| Emmy Award | 1988 | Outstanding Directing for a Drama Series | Winner | Mark Tinker |
| Emmy Award | 1988 | Outstanding Drama Series | Nominee | |
| Emmy Award | 1988 | Outstanding Guest Performer in a Drama Series | Nominee | Alfre Woodard |
| Emmy Award | 1988 | Outstanding Guest Performer in a Drama Series | Nominee | Lainie Kazan |
| Emmy Award | 1988 | Outstanding Supporting Actor in a Drama Series | Nominee | Ed Begley Jr. |
| Emmy Award | 1988 | Outstanding Supporting Actress in a Drama Series | Nominee | Bonnie Bartlett |
| Emmy Award | 1988 | Outstanding Supporting Actress in a Drama Series | Nominee | Christina Pickles |
| Emmy Award | 1988 | Outstanding Writing for a Drama Series | Nominee | Bruce Paltrow, Mark Tinker, Tom Fontana, John Tinker, Channing Gibson |
| Emmy Award | 1987 | Outstanding Guest Performer in a Drama Series | Nominee | Jayne Meadows |
| Emmy Award | 1987 | Outstanding Guest Performer in a Drama Series | Nominee | Steve Allen |
| Emmy Award | 1987 | Outstanding Guest Performer in a Drama Series | Nominee | Edward Herrmann |
| Emmy Award | 1987 | Outstanding Actor in a Drama Series | Nominee | William Daniels |
