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| Award (↑) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| PRISM Award | 2008 | Outstanding Television Drama Series Multi-Episode Storyline | Nominee | |
| PRISM Award | 2007 | Outstanding Television Drama Series Multi-Episode Storyline | Winner | |
| PRISM Award | 2007 | Outstanding Performance in a Drama Series Multi-Episode Storyline | Nominee | Hugh Laurie |
| PRISM Award | 2006 | Outstanding Television Drama Series Episode | Nominee | |
| PRISM Award | 2006 | Outstanding Performance in a Drama Series | Nominee | Hugh Laurie |
| PRISM Award | 2005 | Outstanding Television Drama Series Episode | Winner | |
| RATTY Award | 2008 | Most Improved Series | Nominee | |
| RATTY Award | 2008 | Best Episode of a Drama Series | Nominee | |
| RATTY Award | 2008 | Best Drama Series | Nominee | |
| RATTY Award | 2008 | Best Guest Actress in a Drama Series | Nominee | Anne Dudek |
| RATTY Award | 2008 | Best Guest Actress in a Drama Series | Nominee | Mira Sorvino |
| RATTY Award | 2008 | Best Lead Actor in a Drama Series | Nominee | Hugh Laurie |
| RATTY Award | 2008 | Best Supporting Actor in a Drama Series | Nominee | Robert Sean Leonard |
| RATTY Award | 2007 | Best Drama Series | Nominee | |
| RATTY Award | 2007 | Best Lead Actor in a Drama Series | Winner | Hugh Laurie |
| RATTY Award | 2007 | Best Supporting Actress in a Drama Series | Winner | Lisa Edelstein |
| RATTY Award | 2006 | Best Drama Series | Nominee | |
| RATTY Award | 2006 | Best Guest Actor in a Drama Series | Winner | Elias Koteas |
| RATTY Award | 2006 | Best Lead Actor in a Drama Series | Winner | Hugh Laurie |
| RATTY Award | 2005 | Best Writing in a Drama Series | Nominee | David Shore |
| RATTY Award | 2005 | Best Directing in a Drama Series | Nominee | Paris Barclay |
| RATTY Award | 2005 | Best Drama Series | Nominee | |
| RATTY Award | 2005 | Best Guest Actress in a Drama Series | Winner | Sela Ward |
| RATTY Award | 2005 | Best Lead Actor in a Drama Series | Winner | Hugh Laurie |
| RATTY Award | 2005 | Best New Series | Nominee | |
| Saturn Award | 2006 | Best DVD Television Release | Nominee | |
| Screen Actors Guild Award | 2008 | Outstanding Performance by an Actor in a Television Drama Series | Nominee | Hugh Laurie |
| Screen Actors Guild Award | 2007 | Outstanding Performance by an Actor in a Television Drama Series | Winner | Hugh Laurie |
| Screen Actors Guild Award | 2006 | Outstanding Performance by an Actor in a Television Drama Series | Nominee | Hugh Laurie |
| Teen Choice Award | 2008 | Choice TV Show - Drama | Nominee | |
| Teen Choice Award | 2008 | Choice TV Breakout Star - Female | Nominee | Olivia Wilde |
| Teen Choice Award | 2007 | Choice TV Actor - Drama | Winner | Hugh Laurie |
| Teen Choice Award | 2007 | Choice TV Show - Drama | Nominee | |
| Teen Choice Award | 2006 | Choice TV Actor | Nominee | Hugh Laurie |
| Teen Choice Award | 2006 | Choice TV Show - Drama/Action Adventure | Nominee | |
| Teen Choice Award | 2005 | Choice TV Breakout Performance, Male | Nominee | Jesse Spencer |
| Teen Choice Award | 2005 | Choice TV Breakout Show | Nominee | |
| Teen Choice Award | 2005 | Choice TV Drama Series | Nominee | |
| Television Critics Association Award | 2007 | Outstanding Individual Achievement in a Drama Series | Nominee | Hugh Laurie |
| Television Critics Association Award | 2006 | Outstanding Achievement in a Drama Series | Nominee | |
| Television Critics Association Award | 2006 | Outstanding Individual Achievement in a Drama Series | Winner | Hugh Laurie |
| Television Critics Association Award | 2005 | Outstanding Achievement in a Drama Series | Nominee | |
| Television Critics Association Award | 2005 | Outstanding Individual Achievement in a Drama Series | Winner | Hugh Laurie |
| Television Critics Association Award | 2005 | Outstanding New Program of the Year | Nominee | |
| TelevisionWeek's Critics Poll | 2008.02 | Best Television (#6) | Winner | |
| TelevisionWeek's Critics Poll | 2008.01 | Best Television (#7) | Winner | |
| TelevisionWeek's Critics Poll | 2007.02 | Best Television (#15) | Winner | |
| TelevisionWeek's Critics Poll | 2007.01 | Best Television (#11) | Winner | |
| TelevisionWeek's Critics Poll | 2006.02 | Best Television (#5) | Winner | |
| TelevisionWeek's Critics Poll | 2006.01 | Best Television (#3) | Winner |
