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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| MediaVillage TV Fan Award | 2006 | Outstanding Actor in a Drama Series | Winner | Hugh Laurie |
| Internet TV Award | 2006 | Favorite Primetime Drama Series | Nominee | |
| Internet TV Award | 2006 | Favorite Actor in a Primetime Drama Series | Nominee | Hugh Laurie |
| Humanitas Prize | 2007 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Doris Egan |
| Humanitas Prize | 2006 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Winner | David Shore |
| Humanitas Prize | 2005 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | David Shore |
| Humanitas Prize | 2005 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Sara B. Cooper |
| Hollywood Post Alliance Award | 2006 | Outstanding Compositing in Television | Nominee | Elan Soltes; Kent Feeler; Matt Von Brock; Nick D'Amico |
| Golden Tater Award | 2007 | Best Chemistry (#3) | Voted | Hugh Laurie & Lisa Edelstein |
| Golden Tater Award | 2007 | Godforsaken Love Polygon You're Totally Over (#4) | Voted | Cuddy-House-Cameron-Chase |
| Golden Tater Award | 2007 | Drama King (#1) | Voted | Hugh Laurie |
| Golden Tater Award | 2006 | Favorite Drama King (#2) | Voted | Hugh Laurie |
| Golden Tater Award | 2006 | Best Drama (#5) | Voted | |
| Golden Tater Award | 2005 | Breakout Star, Male (#2) | Voted | Hugh Laurie |
| Golden Satellite Award | 2007 | Best Actor in a Television Drama Series | Nominee | Hugh Laurie |
| Golden Satellite Award | 2006 | Best Actor in a Television Drama Series | Winner | Hugh Laurie |
| Golden Satellite Award | 2006 | Best Actor in a Television Drama Series | Winner | Hugh Laurie |
| Golden Satellite Award | 2006 | Best Supporting Actress in a Television Series, Miniseries or Motion Picture | Winner | Lisa Edelstein |
| Golden Satellite Award | 2006 | Best Television Drama Series | Winner | |
| Golden Satellite Award | 2006 | Best Television Drama Series | Winner | |
| Golden Reel Award (MPSE) | 2008 | Outstanding Sound Editing in Short Form Television - Dialogue and Automated Dialogue Replacement | Winner | |
| Golden Reel Award (MPSE) | 2006 | Outstanding Sound Editing in Short Form Television - Dialogue and Automated Dialogue Replacement | Winner | |
| Golden Reel Award (MPSE) | 2005 | Outstanding Sound Editing in Short Form Television - Sound Effects and Foley | Nominee | |
| Golden Laurel Award | 2007 | Norman Felton Producer of the Year for Episodic Drama Television | Nominee | |
| Golden Globe Award | 2008 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 2008 | Outstanding Actor in a Television Drama Series | Nominee | Hugh Laurie |
| Golden Globe Award | 2007 | Outstanding Actor in a Television Drama Series | Winner | Hugh Laurie |
| Golden Globe Award | 2006 | Outstanding Actor in a Television Drama Series | Winner | Hugh Laurie |
| Golden Gasm Award | 2006 | Best Actor | Nominee | Hugh Laurie |
| Golden Gasm Award | 2006 | Favorite Contender That Almost Got a Nomination But Didn't | Nominee | Best Drama |
| Golden Gasm Award | 2006 | Most Shocking Moment | Nominee | A guy's eyeball pops out and then his testicle explodes |
| Golden Gasm Award | 2005 | Best Actor | Nominee | Hugh Laurie |
| Golden Gasm Award | 2005 | Best Television Series, Scripted | Nominee | |
| futoncritic's Best Eps | 2008 | 50 Best Eps of 2006 (#16) | Winner | |
| futoncritic's Best Eps | 2007 | 50 Best Eps of 2006 (#14) | Winner | |
| futoncritic's Best Eps | 2007 | 50 Best Eps of 2006 (#24) | Winner | |
| futoncritic's Best Eps | 2006 | 50 Best Eps of 2005 (#1) | Winner | |
| futoncritic's Best Eps | 2005 | 50 Best Eps of 2004 (#28) | Winner | |
| EW's All Time Greatest/Worst Lists | 2008 | 100 New TV Classics (#62) | Winner | |
| Environmental Media Association Award | 2005 | Television Episodic Drama | Nominee | |
| Emmy Award | 2008 | Outstanding Directing for a Drama Series | Nominee | Greg Yaitanes |
| Emmy Award | 2008 | Outstanding Drama Series | Nominee | |
| Emmy Award | 2008 | Outstanding Lead Actor in a Drama Series | Nominee | Hugh Laurie |
| Emmy Award | 2008 | Outstanding Music Composition (Original Dramatic Score) for a Series | Nominee | Jon Ehrlich; Jason Derlatka |
| Emmy Award | 2007 | Outstanding Drama Series | Nominee | |
| Emmy Award | 2007 | Outstanding Guest Actor in a Drama Series | Nominee | David Morse |
| Emmy Award | 2007 | Outstanding Lead Actor in a Drama Series | Nominee | Hugh Laurie |
| Emmy Award | 2007 | Outstanding Makeup (Prosthetic) for a Series, Miniseries, Movie or a Special | Winner | Dalia Dokter; Jamie Kelman; Ed French |
| Emmy Award | 2006 | Outstanding Art Direction for a Single-Camera Series | Nominee | Derek R. Hill, Danielle Berman |
| Emmy Award | 2006 | Outstanding Casting for a Drama Series | Nominee | Amy Lippens, Stephanie Laffin |
